I can tell you know that because the Moodle mobile app uses an iframe, responsive content like Adapt will have problems on iOS due to this platforms dreadful handling of content in iframes and framesets.
Adding in the iOSScrollFix extension would probably help with this. Let me try and find out if there's anything else that would need doing.
FYI, Denis Noctor has done some work to update Jamie Smith's Simple pop-up window code from 2014 for Moodle. You can see some info on that here: https://tracker.moodle.org/browse/MDL-46563 and discussion in the forums https://moodle.org/mod/forum/discuss.php?d=339315
It involves tweaking some core code, but it will allow you to open modules in a completely seperate pop-up window, which works well with iOS.